Erik ten Hag hands new signing Noussair Mazraoui a start having signed just this week from Bayern Munich. Mathijs de Ligt also arrived from Bayern Munich this week but he has to settle for the bench alongside fellow new signing Joshua Zirkzee. There is no Jadon Sancho in the squad.
Manchester United: Onana; Mazraoui, Maguire, Martinez, Dalot; Casemiro, Mount, Mainoo; Amad, Fernandes, Rashford
Substitutes: Bayindir, De Ligt, Evans, Collyer, Eriksen, McTominay, Antony, Garnacho, Zirkzee
Marco Silva gives a full debut to Emile Smith-Rowe, who signed from Arsenal this summer. Fellow new signing Jorge Cuenca is on the bench.
Fulham: Leno, Tete, Diop, Bassey, Robinson, Lukic, Pereira, Smith Rowe, Traore, Iwobi, Muniz.
Substitutes: Benda, Castagne, Cuenca, Reed, Cairney, King, Wilson, Jimenez, Stansfield.